Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Trial
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چکیده
منابع مشابه
The Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) trial
Previous trials (Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure [MERIT-HF], Cardiac Insufficiency Bisoprolol Study [CIBIS] II) have demonstrated a mortality benefit of beta-adrenergic blockade in patients with mild to moderate heart failure. The recent Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) trial has extended these results to a more advanc...
متن کاملCarvedilol prospective randomized cumulative survival (COPERNICUS) trial: carvedilol as the sun and center of the beta-blocker world?
Heart failure is a deadly disease that has reached epidemic proportions in industrialized countries. Patients living with heart failure carry a heavy burden in terms of morbidity. Many patients require repeated hospitalizations for cardiovascular problems, especially for episodes of worsening heart failure. In fact, heart failure is one of the most important causes of hospital admissions in the...
متن کاملEffect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study.
BACKGROUND Beta-blocking agents improve functional status and reduce morbidity in mild-to-moderate heart failure, but it is not known whether they produce such benefits in severe heart failure. METHODS AND RESULTS We randomly assigned 2289 patients with symptoms of heart failure at rest or on minimal exertion and with an ejection fraction <25% (but not volume-overloaded) to double-blind treat...
متن کاملA Randomized Prospective Trial
Intervention: Randomly assigned conventional retraction or retraction with the wound-protection system. Patients were blinded to the study arm in which they were enrolled. All patients were given standardized preoperative antibiotics. Demographics including age, sex, body mass index, history of diabetes, and tobacco use were recorded. The severity of appendicitis as determined by the attending ...
متن کاملRandomized trial of carvedilol in treatment of congestive heart failure.
BACKGROUND Members of the U.S. Cardevivol Study Group at Lovelace Scientific Resources, Albuquerque, NM, designed and carried out a large multicenter randomized clinical trial of Cardevilol vs placebo in patients with clinical heart failure and ejection fraction < 0.35. RESULTS Derived exposure and death data at 50-day intervals to 400 days were used to construct tables of comparative mortali...
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ژورنال
عنوان ژورنال: Circulation
سال: 2002
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000038702.35084.d6